Patients commonly present with acute pain secondary to an acute injury, and there are dozens of potential options for addressing their pain. Most trials explore the effectiveness of a treatment option versus placebo or sham therapy, which complicates assessment of comparative effectiveness among competing therapies. We will discuss the role of network meta-analyses to inform comparative effectiveness, despite limited evidence from head-to-head trials.
- An evolving approach for informing comparative effectiveness of competing interventions
- Optimizing interpretation of effect estimates
- Consideration of net benefit (benefits and harms)
- Advantages of a partially contextualized approach to interpreting network estimates vs. surface under the cumulative ranking curve (SUCRA)
Jason Busse DC, PhD
Associate Director, Michael G. DeGroote Centre for Medicinal Cannabis Research
Anesthesia & Health Research Methods, Evidence, and Impact